> in collection MIDAS/ISP: Optical Coherence Tomography in Ophthalmology (Published March 2, 2009)/Article #102748

Please use this identifier to cite or link to this item: http://hdl.handle.net/10376/1248

Title:	Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography
Authors:	Marco Ruggeri1, Gavriil Tsechpenakis2, Shuliang Jiao1, Maria Elena Jockovich1, Colleen Cebulla1, Eleut Hernandez1, Timothy G. Murray1, Carmen A. Puliafito1
Institutions:	1University of Miami Miller School of Medicine, 2University of Miami
Publisher:	Optical Society of America
Publication Date:	2009-Mar-02
Journal:	Optics Express, Vol. 17, Iss. 5, pp. 4074-4083
PDF Article:	http://www.opticsinfobase.org/abstract.cfm?uri=oe-17-5-4074
Abstract:	We have successfully imaged the retinal tumor in a mouse model using an ultra-high resolution spectral-domain optical coherence tomography (SD-OCT) designed for small animal retinal imaging. For segmentation of the tumor boundaries and calculation of the tumor volume, we developed a novel segmentation algorithm. The algorithm is based on parametric deformable models (active contours) and is driven by machine learning-based region classification, namely a Conditional Random Field. With this algorithm we are able to obtain the tumor boundaries automatically, while the user can specify additional constraints (points on the boundary) to correct the segmentation result, if needed. The system and algorithm were successfully applied to studies on retinal tumor progression and monitoring treatment effects quantitatively in a mouse model of retinoblastoma.
Complete Data Collection & Article:	article_102748_full.zip (217Mb)
Compressed Data Collection:	article_102748_preview.zip (1Mb)
Data Collection:	View1 Fig. 1 Case001 normal mouse retina View2 Fig. 3 Case002 Tumor at Week 10 View3 Fig. 3 Case003 Tumor1 at Week 11 View4 Fig. 3 Case004 Tumor1 at Week 12 View5 Fig. 4 Case005 Tumor2 at Week 10 View6 Fig. 4 Case006 Tumor2 at Week 11 view7 Fig. 4 Case007 Tumor2 at Week 12
OCIS codes:	170.4500, 170.3880, 170.4580, 100.2960
	© 2010 Optical Society of America

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