> in collection MIDAS/ISP: Optical Coherence Tomography in Ophthalmology (Published March 2, 2009)/Article #102497

Please use this identifier to cite or link to this item: http://hdl.handle.net/10376/1129

Title:	Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources
Authors:	Barry Cense1, Erik Koperda1, Jeffrey M. Brown1, Omer P. Kocaoglu1, Weihua Gao1, Ravi S. Jonnal1, Donald T. Miller1
Institutions:	1Indiana University
Publisher:	Optical Society of America
Publication Date:	2009-Mar-02
Journal:	Optics Express, Vol. 17, Iss. 5, pp. 4095-4111
PDF Article:	http://www.opticsinfobase.org/abstract.cfm?uri=oe-17-5-4095
Abstract:	Ultrabroadband sources, such as multiplexed superluminescent diodes (SLDs) and femtosecond lasers, have been successfully employed in adaptive optics optical coherence tomography (AO-OCT) systems for ultrahigh resolution retinal imaging. The large cost differential of these sources, however, motivates the need for a performance comparison. Here, we compare the performance of a Femtolasers Integral Ti:Sapphire laser and a Superlum BroadLighter T840, using the same AO-OCT system and the same subject. In addition, we investigate the capability of our instrument equipped with the Integral to capture volume images of the fovea and adjacent regions on a second subject using the AO to control focus in the retina and custom and freeware image registration software to reduce eye motion artifacts. Monochromatic ocular aberrations were corrected with a woofer-tweeter AO system. Coherence lengths of the Integral and BroadLighter were measured in vivo at 3.2 µm and 3.3 µm, respectively. The difference in dynamic range was 5 dB, close to the expected variability of the experiment. Individual cone photoreceptors, retinal capillaries and nerve fiber bundles were distinguished in all three dimensions with both sources. The acquired retinal volumes are provided for viewing in OSA ISP, allowing the reader to data mine at the microscope level.
Media Files:	http://www.opticsinfobase.org/viewmedia.cfm?uri=oe-17-5-4095&seq=1
Complete Data Collection & Article:	article_102497_full.zip (648Mb)
Compressed Data Collection:	article_102497_preview.zip (3Mb)
Data Collection:	Case1 Fig. 5(a) Case001 Integral & BroadLighter... Case2 Fig. 5(b) Case002 Integral & BroadLighter... Case3 Fig. 8 Case003 Integral 1 Case4 Fig. 10(a) Case004 Integral 2 Case5 Fig. 10(b) Case005 Integral 3 Case6 Fig. 10(c) Case006 Integral 4 Case7 Fig. 10(d) Case007 Integral 5 View1 Fig. 8 Case003 Integral 1 View2 Fig. 8 Case003 Integral 1 View3 Fig. 5(a) Case003 Integral 1
OCIS codes:	170.4500, 010.1080, 170.4470, 330.4300, 170.4580
	© 2010 Optical Society of America

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