> in collection MIDAS/ISP: Optical Coherence Tomography in Ophthalmology (Published March 2, 2009)/Article #105211

Please use this identifier to cite or link to this item: http://hdl.handle.net/10376/1280

Title:	Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography
Authors:	Boris Považay1, Bernd Hofer1, Cristiano Torti1, Boris Hermann1, Alexandre R. Tumlinson1, Marieh Esmaeelpour1, Catherine A. Egan2, Alan C. Bird2, Wolfgang Drexler1
Institutions:	1Cardiff University, 2Moorfields Eye Hospital
Publisher:	Optical Society of America
Publication Date:	2009-Mar-02
Journal:	Optics Express, Vol. 17, Iss. 5, pp. 4134-4150
PDF Article:	http://www.opticsinfobase.org/abstract.cfm?uri=oe-17-5-4134
Abstract:	: Recent substantial developments in light source and detector technology have initiated a paradigm shift in retinal optical coherence tomography (OCT) performance. Broad bandwidth light sources in the 800 nm and 1060 nm wavelength region enable axial OCT resolutions of 2-3 μm and 5-7 μm, respectively. Novel high speed silicon based CMOS cameras at 800 nm and InGaAs based CCD cameras in combination with frequency domain OCT technology enable data acquisition speeds of up to 47,000 A-scans/s at 1060 nm and up to 312,500 A-scans/s at 800 nm. Combining ultrahigh axial resolution, ultrahigh speed OCT at 800 nm with pancorrected adaptive optics allows volumetric in vivo cellular resolution retinal imaging. Commercially available three-dimensional (3D) retinal OCT at 800 nm (20,000 A-scans/s, 6 μm axial resolution) is compared to ultrahigh speed 3D retinal imaging at 800 nm (160,000 A-scans/s, 2-3 μm axial resolution), high speed 3D choroidal imaging at 1060 nm (47,000 Ascan/ second, 6-7 μm axial resolution) and cellular resolution retinal imaging at 800 nm using adaptive optics OCT at 160,000 A-scans/second with isotropic resolution of ~2 μm. Analysis of the performance of these four imaging modalities applied in normal and pathologic eyes focusing on motion artifact free volumetric retinal imaging and revealing novel, complementary morphological information due to enhanced resolution, speed and penetration is presented.
Complete Data Collection & Article:	article_105211_full.zip (415Mb)
Compressed Data Collection:	article_105211_preview.zip (4Mb)
Data Collection:	View1 Fig. 1 Case001 normal 3D-OCT 800 nm... View2 Fig. 1 Case002 normal 1060 nm 3D-OCT... View3 Fig. 1 Case003 normal wide field... View4 Fig. 1 Case003 normal wide field... View5 Fig. 1 Case003 normal wide field... View6 Fig. 2 Fig. 2 Case004 Case006 normal AO OCT photorec... MacTel 3D-OCT 800 nm... View7 Fig. 2 Fig. 2 Case005 Case006 normal AO OCT photorec... MacTel 3D-OCT 800 nm... View8 Fig. 3 Case006 MacTel 3D-OCT 800 nm... View9 Fig. 3 Fig. 3 Case007 Case006 MacTel AO OCT at 0° MacTel 3D-OCT 800 nm... View10 Fig. 3 Fig. 3 Case006 Case008 MacTel 3D-OCT 800 nm... MacTel AO OCT at 6° View11 Fig. 4 Fig. 4 Case006 Case009 MacTel 3D-OCT 800 nm... RetPig 3D-OCT 800 nm... View12 Fig. 4 Fig. 4 Case006 Case010 MacTel 3D-OCT 800 nm... RetPig 1060 nm... View13 Fig. 4 Fig. 4 Case011 Case006 RetPig AO OCT at 4° MacTel 3D-OCT 800 nm...
Additional Datasets:	Color Maps
OCIS codes:	110.4500, 170.4470
	© 2010 Optical Society of America

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