MIDAS - Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

MIDAS/ISP: Optical Coherence Tomography in Ophthalmology (Published March 2, 2009)/Article #102748

Please use this identifier to cite or link to this item: http://hdl.handle.net/10376/1248

Title:

Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

Authors:

Marco Ruggeri¹, Gavriil Tsechpenakis², Shuliang Jiao¹, Maria Elena Jockovich¹, Colleen Cebulla¹, Eleut Hernandez¹, Timothy G. Murray¹, Carmen A. Puliafito¹

Institutions:

¹University of Miami Miller School of Medicine, ²University of Miami

Publisher:

Optical Society of America

Publication date:

2009-Mar-02

Journal:

Optics Express, Vol. 17, Iss. 5, pp. 4074-4083

PDF Article:

http://www.opticsinfobase.org/abstract.cfm?uri=oe-17-5-4074

Abstract:

We have successfully imaged the retinal tumor in a mouse model using an ultra-high resolution spectral-domain optical coherence tomography (SD-OCT) designed for small animal retinal imaging. For segmentation of the tumor boundaries and calculation of the tumor volume, we developed a novel segmentation algorithm. The algorithm is based on parametric deformable models (active contours) and is driven by machine learning-based region classification, namely a Conditional Random Field. With this algorithm we are able to obtain the tumor boundaries automatically, while the user can specify additional constraints (points on the boundary) to correct the segmentation result, if needed. The system and algorithm were successfully applied to studies on retinal tumor progression and monitoring treatment effects quantitatively in a mouse model of retinoblastoma.

Complete Data Collection & Article:

article_102748_full.zip (220Mb)

Compressed Data Collection:

article_102748_preview.zip (3Mb)

Data Collection:

View1	Fig. 1	Case001	normal mouse retina
View2	Fig. 3	Case002	Tumor at Week 10
View3	Fig. 3	Case003	Tumor1 at Week 11
View4	Fig. 3	Case004	Tumor1 at Week 12
View5	Fig. 4	Case005	Tumor2 at Week 10
View6	Fig. 4	Case006	Tumor2 at Week 11
view7	Fig. 4	Case007	Tumor2 at Week 12

OCIS Code:

170.4500 , 170.3880 , 170.4580 , 100.2960

Please wait...

Navigation

/midaspub/
Browse
More information
OSA Links
- Optics InfoBase
- OSA - The Optical Society

Download

Retinal tumor imaging and volume quantification in mouse model using spectral-domain optical coherence tomography

Navigation

Browse

More information

OSA Links