MIDAS - Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography

Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography

MIDAS/ISP: Optical Coherence Tomography in Ophthalmology (Published March 2, 2009)/Article #105211

Please use this identifier to cite or link to this item: http://hdl.handle.net/10376/1280

Title:

Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography

Authors:

Boris Považay¹, Bernd Hofer¹, Cristiano Torti¹, Boris Hermann¹, Alexandre R. Tumlinson¹, Marieh Esmaeelpour¹, Catherine A. Egan², Alan C. Bird², Wolfgang Drexler¹

Institutions:

¹Cardiff University, ²Moorfields Eye Hospital

Publisher:

Optical Society of America

Publication date:

2009-Mar-02

Journal:

Optics Express, Vol. 17, Iss. 5, pp. 4134-4150

PDF Article:

http://www.opticsinfobase.org/abstract.cfm?uri=oe-17-5-4134

Abstract:

: Recent substantial developments in light source and detector technology have initiated a paradigm shift in retinal optical coherence tomography (OCT) performance. Broad bandwidth light sources in the 800 nm and 1060 nm wavelength region enable axial OCT resolutions of 2-3 μm and 5-7 μm, respectively. Novel high speed silicon based CMOS cameras at 800 nm and InGaAs based CCD cameras in combination with frequency domain OCT technology enable data acquisition speeds of up to 47,000 A-scans/s at 1060 nm and up to 312,500 A-scans/s at 800 nm. Combining ultrahigh axial resolution, ultrahigh speed OCT at 800 nm with pancorrected adaptive optics allows volumetric in vivo cellular resolution retinal imaging. Commercially available three-dimensional (3D) retinal OCT at 800 nm (20,000 A-scans/s, 6 μm axial resolution) is compared to ultrahigh speed 3D retinal imaging at 800 nm (160,000 A-scans/s, 2-3 μm axial resolution), high speed 3D choroidal imaging at 1060 nm (47,000 Ascan/ second, 6-7 μm axial resolution) and cellular resolution retinal imaging at 800 nm using adaptive optics OCT at 160,000 A-scans/second with isotropic resolution of ~2 μm. Analysis of the performance of these four imaging modalities applied in normal and pathologic eyes focusing on motion artifact free volumetric retinal imaging and revealing novel, complementary morphological information due to enhanced resolution, speed and penetration is presented.

Complete Data Collection & Article:

article_105211_full.zip (429Mb)

Compressed Data Collection:

article_105211_preview.zip (18Mb)

Data Collection:

View1	Fig. 1	Case001	normal 3D-OCT 800 nm...
View2	Fig. 1	Case002	normal 1060 nm 3D-OCT...
View3	Fig. 1	Case003	normal wide field...
View4	Fig. 1	Case003	normal wide field...
View5	Fig. 1	Case003	normal wide field...
View6	Fig. 2 Fig. 2	Case004 Case006	normal AO OCT photorec... MacTel 3D-OCT 800 nm...
View7	Fig. 2 Fig. 2	Case005 Case006	normal AO OCT photorec... MacTel 3D-OCT 800 nm...
View8	Fig. 3	Case006	MacTel 3D-OCT 800 nm...
View9	Fig. 3 Fig. 3	Case007 Case006	MacTel AO OCT at 0° MacTel 3D-OCT 800 nm...
View10	Fig. 3 Fig. 3	Case006 Case008	MacTel 3D-OCT 800 nm... MacTel AO OCT at 6°
View11	Fig. 4 Fig. 4	Case006 Case009	MacTel 3D-OCT 800 nm... RetPig 3D-OCT 800 nm...
View12	Fig. 4 Fig. 4	Case006 Case010	MacTel 3D-OCT 800 nm... RetPig 1060 nm...
View13	Fig. 4 Fig. 4	Case011 Case006	RetPig AO OCT at 4° MacTel 3D-OCT 800 nm...

Additional Datasets:

Color Maps

OCIS Code:

110.4500 , 170.4470

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