MIDAS - (DH)Partially Coherent Lensfree Tomographic Microscopy

(DH)Partially Coherent Lensfree Tomographic Microscopy

MIDAS/ISP: Digital Holography 2011/Article #152120

Title:

(DH)Partially Coherent Lensfree Tomographic Microscopy

Authors:

Aydogan Ozcan¹, Serhan O. Isikman¹, Waheb Bishara¹

Institutions:

¹UCLA

Publisher:

Optical Society of America

Publication date:

Received 2011-Aug-01

PDF Article:

Ozcan-linked.pdf

Abstract:

Optical sectioning of biological specimens provides detailed volumetric information regarding their internal structure. To provide a complementary approach to existing three-dimensional (3D) microscopy modalities, we have recently demonstrated lensfree optical tomography that offers high-throughput imaging within a compact and simple platform. In this approach, in-line holograms of objects at different illumination angles are recorded using a digital sensor-array, which enables computing pixel super-resolved tomographic images of the specimen. This imaging modality, which forms the focus of this review, offers micrometer-scale 3D resolution over large imaging volumes of e.g., 15-100 mm3, and can be assembled in light-weight and compact architectures. Therefore, lensfree optical tomography might be particularly useful for lab-on-a-chip applications as well as for microscopy needs in resource-limited settings.

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